Tissue Transglutaminase, IgA with Reflexes; Total IgA with ReflexIf the Tissue Transglutaminase IgA is positive, Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86255). If the Endomysial Antibody Screen (IgA) is positive, Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256).If the Total IgA is less than the lower limit of the reference range, based on age, Tissue Transglutaminase IgG will be performed at an additional charge (CPT code(s): 83516).
Immunoassay (IA) â¢ Immunoturbidimetric Assay
(tTG) Antibody, (IgA)
Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.