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PROLACTIN

 
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Description
 

CPT Code(s)

84146

Methodology

Immunoassay

Reference Range(s)

Adult Male2.0-18.0ng/mL
Adult Female
Non-Pregnant3.0-30.0ng/mL
Pregnant10.0-209.0ng/mL
Postmenopausal2.0-20.0ng/mL
Stages of Puberty (Tanner Stages)
Female ObservedMale Observed
Stage I3.6.12.0 ng/mL≤10.0 ng/mL
Stage II-III2.6-18.0 ng/mL≤6.1 ng/mL
Stage IV-V3.2-20.0 ng/mL2.8-11.0 ng/mL

Clinical Significance

During pregnancy and postpartum lactation, serum prolactin can increase 10- to 20-fold. Exercise, stress, and sleep also cause transient increases in prolactin levels. Consistently elevated serum prolactin levels (>30 ng/mL), in the absence of pregnancy and postpartum lactation, are indicative of hyperprolactinemia. Hypersecretion of prolactin can be caused by pituitary adenomas, hypothalamic disease, breast or chest wall stimulation, renal failure or hypothyroidism. A number of drugs, including many antidepressants, are also common causes of abnormally elevated prolactin levels. Hyperprolactinemia often results in galactorrhea, amenorrhea, and infertility in females, and in impotence and hypogonadism in males. Renal failure, hypothyroidism, and prolactin-secreting pituitary adenomas are also common causes of abnormally elevated prolactin levels.


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