Thyroglobulin Panel

CPT Code(s)

84432,86800

Includes

Thyroglobulin, Thyroglobulin Antibodies

Clinical Significance

Thyroglobulin (TG) is a secretory product only of the thyroid gland. The major clinical use of serum TG measurement is to monitor, but not to diagnose, patients with well-differentiated thyroid cancers. The measurement of thyroglobulin, after thyroidectomy and ablation of the thyroid gland, is useful to determine metastasis. Deficient TG synthesis is observed in infants with goitrous hypo-thyroidism. Most patients with thyroid autoimmune disease have thyroglobulin antibody. With immunometric assays (sandwich assays), TGAB interference typically produces inappropriately low TG results, most likely caused by endogenous TG immune complexes that block one or more of the reagent antibodies from binding endogenous TG.

Alternative Name(s)

TG and ATG,ATG and TG

Preferred Specimen(s)

2 mL serum

Minimum Volume

1 mL

Transport Container

Serum Separator Tube (SST^®)

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria

Gross hemolysis • Gross lipemia

Methodology

Immunoassay (IA)

Performing Laboratory

Setup Schedule

Set up: Tues-Sat a.m.; Report available: 2-3 days

Reference Range(s)

See individual tests