Cyclic Citrullinated Peptide Antibody IgG Blood Test

Synonyms: ACPA, Anti-CCP, CCP Antibody, Anti-cyclic Citrullinated Peptide, Citrulline Antibody, Anti-citrulline Antibody

CPT Code(s)

86200

Methodology

Immunoassay (IA)

Limitations

The presence of immune complexes may cause false-positive results due to increased non-specific binding.

Reference Range(s)

Clinical Significance

A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor. Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about 2% of random blood donors and disease controls subjects are positive.

Alternative Name(s)

Citrullinated Peptide (CCP) IgG,CCP,Anti-Cyclic Citrullinated Peptide (CCP) Antibody IgG