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IGF I, Insulin-like growth factor

 
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Description
 

CPT Code(s)

84305

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)

Reference Range(s)

See Laboratory Report

Clinical Significance

Insulin-like growth factor I (IGF-I, or somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by growth hormone (GH) and nutritional intake. IGF-I is transported in serum by several proteins; this helps maintain relatively high IGF-I plasma levels and minimizes fluctuations in serum IGF-I concentrations.
Measuring IGF-I is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-I, while acromegaly (growth hormone excess) results in elevated levels of IGF-I. IGF-I measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.

Alternative Name(s)

Somatomedin-C,Insulin-Like Growth Factor,IGF-1


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