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COLLAGEN CROSS-LINK
COLLAGEN CROSS-LINK
 
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Description
 

CPT Code(s)

82523, 82570

Includes

Creatinine

Methodology

Enhanced Chemiluminescence

Reference Range(s)

Collagen Cross-Linked N-Telopeptide (NTx), Random Urine

Male
18-29 Years12-99 nmol BCE/mmol creat
30-59 Years9-60 nmol BCE/mmol creat
Female
Premenopausal4-64 nmol BCE/mmol creat
Results are primarily used for monitoring the response to therapy. A value within the premenopausal reference range does not rule out osteoporosis nor the need for therapy.
Creatinine, Random, Urine
≤6 Months2-32 mg/dL
7-11 Months 2-36 mg/dL
1-2 Years2-128 mg/dL
3-8 Years2-149 mg/dL
9-12 Years2-183 mg/dL
>12 Years Male20-370 mg/dL
>12 Years Female20-320 mg/dL

Clinical Significance

NTx is useful to assess bone resorption in patients with metabolic bone disease. The test is also useful in monitoring therapy to slow or halt osteoporotic bone loss. A decline of 30% or more of NTx over a six-month period suggests effective therapy.

Alternative Name(s)

Collagen Cross-Linked N-Telopeptide, N-Telopeptide or NTx

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