Liver dysfunction and other factors can cause a reduction in the clearance of serum ferritin resulting in an increase in serum ferritin levels. Ferritin is an acute phase reactant that may be elevated in a wide-range of inflammatory conditions and infections. Clinical studies suggest the sensitivity may be 35-48% and specificity of 75-78% to detect iron deficiency.
Useful in the diagnosis of hypochromic, microcytic anemias. Decreased in iron deficiency anemia and increased in iron overload.