Fibrinogen Activity, Clauss

This testing is used to evaluate fibrinogen, a protein that is essential for blood clot formation. When there is an injury and bleeding occurs, the body forms a blood clot through a series of steps. In one of the last steps, soluble fibrinogen is converted into insoluble fibrin threads that crosslink together to form a net that stabilizes and adheres at the injury site until the area has healed.

Two types of tests are available:

• A fibrinogen activity test measures the function of fibrinogen and its ability to be converted into fibrin. It is used:
  • As part of an investigation of a possible bleeding disorder or inappropriate blood clot formation (thrombotic episode)
  • As a follow-up to an abnormal bleeding disorder test (prothrombin time, PT or partial thromboplastin time, PTT) and/or an episode of prolonged or unexplained bleeding
  • Along with tests such as PT, PTT, platelet function tests, fibrin degradation products (FDP), and D-dimer to help diagnose disseminated intravascular coagulation (DIC) or abnormal fibrinolysis
  • Occasionally to help monitor the status of a progressive disease (such as liver disease) over time or, rarely, to monitor treatment of an acquired condition (such as DIC)
  • Sometimes along with other cardiac risk markers such as C-reactive protein (CRP) to help determine a person's overall risk of developing cardiovascular disease. This use of the test has not gained widespread acceptance though because there are no direct treatments for elevated levels. However, many health practitioners feel that fibrinogen activity measurements give them additional information that may lead them to be more aggressive in treating those risk factors that they can treat (such as unhealthy levels of cholesterol).
• A fibrinogen antigen test is occasionally ordered as a follow-up test to determine whether decreased fibrinogen activity is due to insufficient fibrinogen or dysfunctional fibrinogen (caused by inherited or acquired dysfibrinogenemia).

A health practitioner may order a fibrinogen activity test when someone:

• Has unexplained or prolonged bleeding
• Has a thrombosis
• Has an abnormal PT and PTT test result
• Has symptoms of or is undergoing treatment for DIC or abnormal fibrinolysis
• May have an inherited or acquired coagulation factor (clotting protein) deficiency or dysfunction
• Has an acquired bleeding disorder and the person's health practitioner wants to evaluate and monitor their clotting ability (over time)

A fibrinogen antigen test may be performed when someone has a low result on a fibrinogen activity test to help determine whether it is due to insufficient or dysfunctional fibrinogen.

High fibrinogen levels have also been associated with coronary heart disease, myocardial infarction, and peripheral arterial disease. In some cases, fibrinogen activity testing is performed along with other tests when a health practitioner wants to evaluate an individual's risk of developing cardiovascular disease.

Fibrinogen test results are reported as the concentration of the protein in the blood. Fibrinogen activity tests are converted into concentrations for comparison with fibrinogen antigen results.

Normal fibrinogen activity results usually reflect normal blood clotting ability.

Significantly decreased fibrinogen activity may be due to decreased or dysfunctional fibrinogen. Reduced fibrinogen activity and antigen levels may impair the body's ability to form a stable blood clot.

Chronically low levels may be related to decreased production due to an inherited condition such as afibrinogenemia or hypofibrinogenemia or to an acquired condition such as end-stage liver disease or severe malnutrition.

Acutely low levels are often related to consumption of fibrinogen such as may be seen with disseminated intravascular coagulation (DIC) and abnormal fibrinolysis, which occurs when the body is overactive in clearing blood clots. Reduced fibrinogen levels may also occur following rapid, large-volume blood transfusions and in people who are malnourished.

Sometimes a health practitioner will use a ratio of the antigen test and the activity test. This is to help to distinguish dysfibrinogenemia (high ratio) from hypofibrinogenemia (ratio close to 1).

Fibrinogen is an acute phase reactant, meaning that fibrinogen concentrations may rise sharply in any condition that causes inflammation or tissue damage. Elevated concentrations of fibrinogen are not specific; that is, they do not tell the health practitioner the cause or location of the disturbance. Usually these elevations in the fibrinogen level are temporary, returning to normal after the underlying condition has been resolved. Elevated levels may be seen with:

• Acute infections
• Cancer
• Coronary heart disease, myocardial infarction
• Stroke
• Inflammatory disorders (like rheumatoid arthritis and glomerulonephritis, a form of kidney disease)
• Trauma
• Cigarette smoking
• Pregnancy
• Peripheral artery disease

While fibrinogen levels are elevated, a person's risk of developing a blood clot may be increased and, over time, they could contribute to an increased risk for developing cardiovascular disease.

Blood transfusions within the past month may affect fibrinogen test results.

Certain drugs may cause decreased levels, including anabolic steroids, phenobarbital, streptokinase, urokinase, L-asparaginase, tissue plasmogen activators, and valproic acid. Moderate elevations in fibrinogen are sometimes seen with pregnancy, cigarette smoking, and with oral contraceptives or estrogen use.

Dysfibrinogenemia is a rare coagulation disorder caused by mutations in the gene controlling the production of fibrinogen in the liver. It causes the liver to make an abnormal, dysfunctional fibrinogen, one that resists degradation when converted to fibrin or can not function normally in the coagulation cascade. Dysfibrinogenemia may increase a person's risk of venous thrombosis or, rarely, cause a mild bleeding tendency. People with fibrinogen deficiency or dysfibrinogenemia may experience poor wound healing.

Genetic molecular testing is occasionally performed for those with inherited dysfibrinogenemia, hypofibrinogenemia, or afibrinogenemia to identify the genetic mutation responsible. Testing for this mutation may also be performed for other family members.

People with liver disease may develop acquired dysfibrinogenemia that could contribute to bleeding or thrombosis.