CPT Code(s)

87621

Methodology

Transcription-Mediated Amplification (TMA)

Reference Range(s)

Not detected

This test was performed using the APTIMA® HPV Assay (Gen-Probe Inc.).

Clinical Significance

The presence of E6/E7 messenger RNA from 14 high risk HPV types indicates incorporation of HPV DNA into the host cells. Proteins expressed from E6-E7 polycistronic mRNA alter cellular p53 and retinoblastoma protein functions, leading to disruption of cell-cycle check points and cell genome instability. This information, together with the physician’s assessment of cytology history, other risk factors, and professional guidelines, may be used to guide patient management.

Test FAQ

HPV mRNA E6/E7

Alternative Name(s)

Hologic,E6/E7, TMA